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  Michael R.J. Forstner, Ph.D.

 

 Genetics 2450

     Class Syllabus

     Sample Exam 1

     Sample Exam 2

     Sample Exam 3

     Sample Final

      

  Lab Syllabus

 

  Lab Manual

      Intro Material

     General Info

     Genetics Lab Papers         

     Writing Papers

     PopGen Lab Res. Paper

     

Genetics 2450

 

Sample Examination

 

    

Instructions: This is a closed book, closed note, INDIVIDUAL examination. You may, however, have a calculator, and use the scratch paper provided to assist with working the problems on this exam. The exam is 25 questions long. Each question is worth 5 points. Show your work where appropriate to provide the opportunity for you to receive partial credit. I appreciate your meeting the highest standards of scholastic honesty while taking this exam.

Circle and Write your selection for each question. Good luck.

 

1.  During meiosis, the X and Y chromosomes pair as homologs, although there is never any crossing over between them. 

If a gamete is produced that contains two Y chromosomes (by mistake), at which division did the nondisjunctional event take place?

 

a.  second division   

b.  first division         

c.  could have been either   

d.  the event must have been premeiotic   

e.  none of these

 

2.  Two homologous chromosomes fail to pair during prophase of meiosis. Which of the following is likely to occur as a result?

 

a.  Crossing over is eliminated       

b.  Creates a high probability of nondisjunction                

c.  both a. and b. are correct           

d.  the chromosomes fail to replicate

e.  The cell fails to divide

 

3.  If the F2 of a dihybrid cross gives a 12:3:1 ratio, what will be the ratio of phenotypes if one takes an F1 individual (from the same cross) and test crosses it?

 

a. 1:1:1:1      

b. 3:1                

c. 2:1:1             

d. 3:3:1               

e. 3:1:1

 

4.  If a couple has 7 children, what is the probability of their having 3 girls and then having 4 boys?

 

a. 1/2           

b. 1/144            

c. 1/128              

d. 1/256                

e. none of these

 

5.  If a couple has 7 children, what is the probability of their having 3 girls and 4 boys?

 

a. 1/2           

b. 21/128          

c. 70/128            

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d. 35/128             

e. none of these

 

6.  If a couple has 7 children, what is the probability of their having 3 or more girls?

 

a. 35/128       

b. 70/128          

c. 99/128            

d. 119/128            

e. none of these

 

7.  If the following cross is made:    AaBbccddEe x aaBbCcDdee

>what is the probability of obtaining an individual that expresses the recessive phenotype for all 5 loci? 

 

a. 1/128         

b. 1/64              

c. 3/64                

d. 9/64                 

e. 27/64


8.  The ability to taste the compound phenylthiourea is dominant. IF both parents are heterozygous for the taster allele (Tt), what is the probability of having a family of 4 consisting of two tasters and two non-tasters?

 

a. 1/256        

b. 6/256      

c. 36/256      

d. 54/256  

e. none of these

 

9.  In peas, tall (plant) is dominant to short, and round (seed) is dominant to wrinkled.  A plant that is heterozygous for both loci is crossed to an unknown plant.  The progeny that result are: 598 tall round: 210 tall wrinkled: 602 short round: and 198 short wrinkled.  What was the phenotype of the unknown plant?

 

a. Tall round  

b. Tall wrinkled    

c. Short round     

d. Short wrinkled     

e. It cannot be determined 

 

10.  A tall round pea plant, when allowed to self pollinate, produces a 9:3:3:1 ratio of tall round: tall wrinkled: short round: short wrinkled.  What ratio would result if this plant were crossed to a homozygous (true breeding) plant that was short wrinkled?

 

a.  1:1: 1:1 ratio of tall round: tall wrinkled: short round: short wrinkled

b.  1:1 ratio of tall round: tall wrinkled

c.  3:1 ratio of tall round: short wrinkled

d.  3:1 ratio of tall round: tall wrinkled

e.  None of these

 

11.  In Drosophila, yellow body (y) is sex linked and recessive.  Brown eyes (bw) is autosomal and recessive.  A yellow brown male is crossed to a homozygous wild-type female producing an F1 in which both males and females are phenotypically wild-type.  The F1 are inbred to form an F2.At what frequency (of total flies) would you expect to find a yellow (but not brown) male in the F2.

 

a. 1/16          

b. 3/16             

c. 4/16                 

d. 6/16                   

e. 9/16

 

12.  See problem 11.At what frequency would you expect to find a yellow brown female in the F2.  

      

a. 1/16          

b. 3/16               

c. 4/16                 

d. 6/16                  

e. none of these

 

13.  Cystic fibrosis is inherited as an autosomal recessive.  Two parents without cystic fibrosis have two children with cystic fibrosis and three children without.  They have come to you for genetic counseling.  What is the numerical probability that their next child will have cystic fibrosis?       

 

a.  0            

b. 16/128           

c. 96/256             

d. 1/4                   

e. none of these

 

14.  See Problem 13.Their unaffected children are concerned about being heterozygous.  What is the numerical probability that a given unaffected child in the family is heterozygous?  

   

a. 0            

b. 2/3                 

c. 1/3                 

d. 3/4                  

e. none of these

 

15.  A three generation pedigree for a particular human trait is shown in the following figure:

 

Y-linked can be excluded at a glance. What is the mode of inheritance for this trait? 

You may assume complete penetrance and  full expressivity for the trait.

            

a. X linked dominant            

b. Autosomal dominant

c. X linked recessive                       

d. Autosomal recessive

e. either a or b

 

16.  Mendel�s laws and where each occurs in Meiosis are as follows:

 

a.  The principle of segregation states that two members of a gene pair segregate from each other in the formation of gametes�demonstrated in Anaphase 1

    The principle of  independent assortment states that the genes for different traits assort independently of each other (Metaphase 1)

 

b.  The principle of segregation states that two members of a gene pair segregate from each other in the formation  of gametes� demonstrated in Metaphase 1

    The principle of independent assortment states that the genes for different traits assort independently of each other (anaphase 1)

 

c.  The principle of independent assortment states that two members of a gene pair segregate from each other in the formation of gametes� demonstrated in Anaphase 1

     The principle of segregation states that the genes for different traits assort independently of each other (Metaphase 1)

 

 

17.  Mendel�s law of independent assortment is violated by  

 

a. nondisjunction  

b. linkage       

c. inversions        

d. none of these


18.  What year (+/- 20 years) did Mendel publish his work?

 

a. 1950               

b. 1850          

c. 1750              

d. 1650                 

e. 1550

 

19.  In Jimsonweed purple flowers are dominant to white. When a particular purple flowered Jimsonweed is self-fertilized, there are 28 purple-flowered and 10 white-flowered progeny.  What proportion of the purple-flowered progeny will breed true?

 

a. 3/4                 

b. 1/2             

c. 2/3                

d. 1/3                   

e. 1/4

 

20.  The cross of an uncertain genotype with a homozygous recessive genotype at the same locus is a 

 

a.  pure breeding cross

b.  monohybrid cross

c.  testcross

d.  dihybrid cross